Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models

A novel pathway of vitamin D(3) (D(3)) metabolism, initiated by C20-hydroxylation of D(3) by CYP11A1, has been confirmed to operate in vivo. Its major product, 20(OH)D(3), exhibits antiproliferative activity in vitro comparable to that of 1,25(OH)(2)D(3), but is noncalcemic in mice and rats. To furt...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Skobowiat, Cezary, Oak, Allen S.W., Kim, Tae-Kang, Yang, Chuan He, Pfeffer, Lawrence M., Tuckey, Robert C., Slominski, Andrzej T.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354773/
https://ncbi.nlm.nih.gov/pubmed/28039464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14193
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