Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models

A novel pathway of vitamin D(3) (D(3)) metabolism, initiated by C20-hydroxylation of D(3) by CYP11A1, has been confirmed to operate in vivo. Its major product, 20(OH)D(3), exhibits antiproliferative activity in vitro comparable to that of 1,25(OH)(2)D(3), but is noncalcemic in mice and rats. To furt...

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Udgivet i:Oncotarget
Main Authors: Skobowiat, Cezary, Oak, Allen S.W., Kim, Tae-Kang, Yang, Chuan He, Pfeffer, Lawrence M., Tuckey, Robert C., Slominski, Andrzej T.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354773/
https://ncbi.nlm.nih.gov/pubmed/28039464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14193
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