Noncalcemic Vitamin D Hydroxyderivatives Inhibit Human Oral Squamous Cell Carcinoma and Down-regulate Hedgehog and WNT/β-Catenin Pathways

BACKGROUND/AIM: 1,25(OH)(2)D(3) Demonstrated activity against oral squamous cell carcinoma (OSCC). Cytochrome P450scc (CYP11A1)-derived vitamin D hydroxyderivatives, such as 20(OH)D(3) and 1,20(OH)(2)D(3), have overlapping beneficial effects with 1,25(OH)(2)D(3) without causing hypercalcemia. This s...

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Udgivet i:Anticancer Res
Main Authors: OAK, ALLEN S.W., BOCHEVA, GEORGETA, KIM, TAE-KANG, BROŻYNA, ANNA A., JANJETOVIC, ZORICA, ATHAR, MOHAMMAD, TUCKEY, ROBERT C., SLOMINSKI, ANDRZEJ T.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7241289/
https://ncbi.nlm.nih.gov/pubmed/32366390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21873/anticanres.14216
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