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Noncalcemic Vitamin D Hydroxyderivatives Inhibit Human Oral Squamous Cell Carcinoma and Down-regulate Hedgehog and WNT/β-Catenin Pathways
BACKGROUND/AIM: 1,25(OH)(2)D(3) Demonstrated activity against oral squamous cell carcinoma (OSCC). Cytochrome P450scc (CYP11A1)-derived vitamin D hydroxyderivatives, such as 20(OH)D(3) and 1,20(OH)(2)D(3), have overlapping beneficial effects with 1,25(OH)(2)D(3) without causing hypercalcemia. This s...
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| Veröffentlicht in: | Anticancer Res |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7241289/ https://ncbi.nlm.nih.gov/pubmed/32366390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21873/anticanres.14216 |
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