Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models

A novel pathway of vitamin D(3) (D(3)) metabolism, initiated by C20-hydroxylation of D(3) by CYP11A1, has been confirmed to operate in vivo. Its major product, 20(OH)D(3), exhibits antiproliferative activity in vitro comparable to that of 1,25(OH)(2)D(3), but is noncalcemic in mice and rats. To furt...

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Vydáno v:Oncotarget
Hlavní autoři: Skobowiat, Cezary, Oak, Allen S.W., Kim, Tae-Kang, Yang, Chuan He, Pfeffer, Lawrence M., Tuckey, Robert C., Slominski, Andrzej T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354773/
https://ncbi.nlm.nih.gov/pubmed/28039464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14193
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