Investigation of 20S-hydroxyvitamin D(3) analogs and their 1α-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities

20S-hydroxyvitamin D(3) [20S(OH)D(3)] is anti-inflammatory and not hypercalcemic, suggesting its potential as a lead compound. In this study, side chain modified 20S(OH)D(3) analogs (4, 13, 23 and 33) together with their 1α-OH derivatives were synthesized and their metabolism and biological activiti...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lin, Zongtao, Marepally, Srinivasa R., Goh, Emily S. Y., Cheng, Chloe Y. S., Janjetovic, Zorica, Kim, Tae-Kang, Miller, Duane D., Postlethwaite, Arnold E., Slominski, Andrzej T., Tuckey, Robert C., Peluso-Iltis, Carole, Rochel, Natacha, Li, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784132/
https://ncbi.nlm.nih.gov/pubmed/29367669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19183-7
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