Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis

[Image: see text] Bromodomains (BRDs) are epigenetic interaction domains currently recognized as emerging drug targets for development of anticancer or anti-inflammatory agents. In this study, development of a selective ligand of the fifth BRD of polybromo protein-1 (PB1(5)) related to switch/sucros...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Myrianthopoulos, Vassilios, Gaboriaud-Kolar, Nicolas, Tallant, Cynthia, Hall, Michelle-Lynn, Grigoriou, Stylianos, Brownlee, Peter Moore, Fedorov, Oleg, Rogers, Catherine, Heidenreich, David, Wanior, Marek, Drosos, Nikolaos, Mexia, Nikitia, Savitsky, Pavel, Bagratuni, Tina, Kastritis, Efstathios, Terpos, Evangelos, Filippakopoulos, Panagis, Müller, Susanne, Skaltsounis, Alexios-Leandros, Downs, Jessica Ann, Knapp, Stefan, Mikros, Emmanuel
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2016
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5301280/
https://ncbi.nlm.nih.gov/pubmed/27617704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00355
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