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A biomimetic, one-step transformation of simple indolic compounds to Malassezia-related alkaloids with high AhR potency and efficacy

Malassezia furfur isolates from diseased skin preferentially biosynthesize compounds which are among the most active known Aryl-hydrocarbon Receptor (AhR) inducers, such as indirubin, tryptanthrin, indolo[3,2-b]carbazole and 6-formylindolo[3,2-b]carbazole. In our effort to study their production fro...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Mexia, Nikitia, Koutrakis, Stamatis, He, Guochun, Skaltsounis, Alexios-Leandros, Denison, Michael S., Magiatis, Prokopios
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7757739/
https://ncbi.nlm.nih.gov/pubmed/31647221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.9b00270
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