Targeting the Protein Ubiquitination Machinery in Melanoma by the NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924)

BACKGROUND: The neddylation pathway conjugates NEDD8 to cullin-RING ligases and controls the proteasomal degradation of specific proteins involved in essential cell processes. Pevonedistat (MLN4924) is a selective small molecule targeting the NEDD8-activating enzyme (NAE) and inhibits an early step...

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Publicado en:Invest New Drugs
Autores principales: Wong, Kit Man, Micel, Lindsey N., Selby, Heather M., Tan, Aik Choon, Pitts, Todd M., Bagby, Stacey M., Spreafico, Anna, Klauck, Peter J., Blakemore, Stephen J., Smith, Peter F., McDonald, Alice, Berger, Allison, Tentler, John J., Eckhardt, S. Gail
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296256/
https://ncbi.nlm.nih.gov/pubmed/27783255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-016-0398-8
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