Targeting the Protein Ubiquitination Machinery in Melanoma by the NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924)

BACKGROUND: The neddylation pathway conjugates NEDD8 to cullin-RING ligases and controls the proteasomal degradation of specific proteins involved in essential cell processes. Pevonedistat (MLN4924) is a selective small molecule targeting the NEDD8-activating enzyme (NAE) and inhibits an early step...

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Bibliografiset tiedot
Julkaisussa:Invest New Drugs
Päätekijät: Wong, Kit Man, Micel, Lindsey N., Selby, Heather M., Tan, Aik Choon, Pitts, Todd M., Bagby, Stacey M., Spreafico, Anna, Klauck, Peter J., Blakemore, Stephen J., Smith, Peter F., McDonald, Alice, Berger, Allison, Tentler, John J., Eckhardt, S. Gail
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296256/
https://ncbi.nlm.nih.gov/pubmed/27783255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-016-0398-8
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