Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile

The application of primary human hepatocytes following isolation from human tissue is well accepted to be compromised by the process of dedifferentiation. This phenomenon reduces many unique hepatocyte functions, limiting their use in drug disposition and toxicity assessment. The aetiology of dediff...

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Veröffentlicht in:Arch Toxicol
Hauptverfasser: Heslop, James A., Rowe, Cliff, Walsh, Joanne, Sison-Young, Rowena, Jenkins, Roz, Kamalian, Laleh, Kia, Richard, Hay, David, Jones, Robert P., Malik, Hassan Z., Fenwick, Stephen, Chadwick, Amy E., Mills, John, Kitteringham, Neil R., Goldring, Chris E. P., Kevin Park, B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2016
Schlagworte:
Organ Toxicity and Mechanisms
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225178/
https://ncbi.nlm.nih.gov/pubmed/27039104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1694-y
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