Donor‐Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte‐Like Cells

Drug‐induced liver injury is the greatest cause of post‐marketing drug withdrawal; therefore, substantial resources are directed toward triaging potentially dangerous new compounds at all stages of drug development. One of the major factors preventing effective screening of new compounds is the lack...

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Opis bibliograficzny
Wydane w:Stem Cells Transl Med
Główni autorzy: Heslop, James A., Kia, Richard, Pridgeon, Christopher S., Sison‐Young, Rowena L., Liloglou, Triantafillos, Elmasry, Mohamed, Fenwick, Stephen W., Mills, John S., Kitteringham, Neil R., Goldring, Chris E., Park, Bong K.
Format: Artigo
Język:Inglês
Wydane: John Wiley and Sons Inc. 2017
Hasła przedmiotowe:
Translational Research Articles and Reviews
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442714/
https://ncbi.nlm.nih.gov/pubmed/28456008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.16-0029
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