Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes

BACKGROUND & AIMS: Hepatocyte-like cells (HLCs), differentiated from pluripotent stem cells by the use of soluble factors, can model human liver function and toxicity. However, at present HLC maturity and whether any deficit represents a true fetal state or aberrant differentiation is unclear an...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Hepatol
Prif Awduron: Baxter, Melissa, Withey, Sarah, Harrison, Sean, Segeritz, Charis-Patricia, Zhang, Fang, Atkinson-Dell, Rebecca, Rowe, Cliff, Gerrard, Dave T., Sison-Young, Rowena, Jenkins, Roz, Henry, Joanne, Berry, Andrew A., Mohamet, Lisa, Best, Marie, Fenwick, Stephen W., Malik, Hassan, Kitteringham, Neil R., Goldring, Chris E., Piper Hanley, Karen, Vallier, Ludovic, Hanley, Neil A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334496/
https://ncbi.nlm.nih.gov/pubmed/25457200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2014.10.016
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