Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation

Failure to predict hepatotoxic drugs in preclinical testing makes it imperative to develop better liver models with a stable phenotype in culture. Stem cell-derived models offer promise, with differentiated hepatocyte-like cells currently considered to be “fetal-like” in their maturity. However, thi...

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Hlavní autoři: Rowe, Cliff, Gerrard, Dave T, Jenkins, Roz, Berry, Andrew, Durkin, Kesta, Sundstrom, Lars, Goldring, Chris E, Park, B Kevin, Kitteringham, Neil R, Hanley, Karen Piper, Hanley, Neil A
Médium: Artigo
Jazyk:Inglês
Vydáno: WILEY-VCH Verlag 2013
Témata:
Liver Biology/Pathobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842115/
https://ncbi.nlm.nih.gov/pubmed/23526496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26414
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