Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile

The application of primary human hepatocytes following isolation from human tissue is well accepted to be compromised by the process of dedifferentiation. This phenomenon reduces many unique hepatocyte functions, limiting their use in drug disposition and toxicity assessment. The aetiology of dediff...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Heslop, James A., Rowe, Cliff, Walsh, Joanne, Sison-Young, Rowena, Jenkins, Roz, Kamalian, Laleh, Kia, Richard, Hay, David, Jones, Robert P., Malik, Hassan Z., Fenwick, Stephen, Chadwick, Amy E., Mills, John, Kitteringham, Neil R., Goldring, Chris E. P., Kevin Park, B.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Organ Toxicity and Mechanisms
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225178/
https://ncbi.nlm.nih.gov/pubmed/27039104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1694-y
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