Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile

The application of primary human hepatocytes following isolation from human tissue is well accepted to be compromised by the process of dedifferentiation. This phenomenon reduces many unique hepatocyte functions, limiting their use in drug disposition and toxicity assessment. The aetiology of dediff...

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Udgivet i:Arch Toxicol
Main Authors: Heslop, James A., Rowe, Cliff, Walsh, Joanne, Sison-Young, Rowena, Jenkins, Roz, Kamalian, Laleh, Kia, Richard, Hay, David, Jones, Robert P., Malik, Hassan Z., Fenwick, Stephen, Chadwick, Amy E., Mills, John, Kitteringham, Neil R., Goldring, Chris E. P., Kevin Park, B.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2016
Fag:
Organ Toxicity and Mechanisms
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225178/
https://ncbi.nlm.nih.gov/pubmed/27039104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1694-y
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