Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile

The application of primary human hepatocytes following isolation from human tissue is well accepted to be compromised by the process of dedifferentiation. This phenomenon reduces many unique hepatocyte functions, limiting their use in drug disposition and toxicity assessment. The aetiology of dediff...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Arch Toxicol
Main Authors: Heslop, James A., Rowe, Cliff, Walsh, Joanne, Sison-Young, Rowena, Jenkins, Roz, Kamalian, Laleh, Kia, Richard, Hay, David, Jones, Robert P., Malik, Hassan Z., Fenwick, Stephen, Chadwick, Amy E., Mills, John, Kitteringham, Neil R., Goldring, Chris E. P., Kevin Park, B.
פורמט: Artigo
שפה:Inglês
יצא לאור: Springer Berlin Heidelberg 2016
נושאים:
Organ Toxicity and Mechanisms
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225178/
https://ncbi.nlm.nih.gov/pubmed/27039104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1694-y
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