Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet?

Amongst the different types of adverse drug reactions, drug-induced liver injury is the most prominent cause of patient morbidity and mortality. However, the current available hepatic model systems developed for evaluating safety have limited utility and relevance as they do not fully recapitulate a...

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Библиографические подробности
Главные авторы: Kia, Richard, Sison, Rowena L C, Heslop, James, Kitteringham, Neil R, Hanley, Neil, Mills, John S, Park, B Kevin, Goldring, Chris E P
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Science Inc 2013
Предметы:
Stem Cells: Pharmacology and Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612706/
https://ncbi.nlm.nih.gov/pubmed/22703588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04360.x
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