Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile

The application of primary human hepatocytes following isolation from human tissue is well accepted to be compromised by the process of dedifferentiation. This phenomenon reduces many unique hepatocyte functions, limiting their use in drug disposition and toxicity assessment. The aetiology of dediff...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Arch Toxicol
Glavni autori: Heslop, James A., Rowe, Cliff, Walsh, Joanne, Sison-Young, Rowena, Jenkins, Roz, Kamalian, Laleh, Kia, Richard, Hay, David, Jones, Robert P., Malik, Hassan Z., Fenwick, Stephen, Chadwick, Amy E., Mills, John, Kitteringham, Neil R., Goldring, Chris E. P., Kevin Park, B.
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2016
Teme:
Organ Toxicity and Mechanisms
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225178/
https://ncbi.nlm.nih.gov/pubmed/27039104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1694-y
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items