Osteopontin Is a Novel Downstream Target of SOX9 With Diagnostic Implications for Progression of Liver Fibrosis in Humans

Osteopontin (OPN) is an important component of the extracellular matrix (ECM), which promotes liver fibrosis and has been described as a biomarker for its severity. Previously, we have demonstrated that Sex-determining region Y-box 9 (SOX9) is ectopically expressed during activation of hepatic stell...

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Bibliographic Details
Main Authors: Pritchett, James, Harvey, Emma, Athwal, Varinder, Berry, Andrew, Rowe, Cliff, Oakley, Fiona, Moles, Anna, Mann, Derek A, Bobola, Nicoletta, Sharrocks, Andrew D, Thomson, Brian J, Zaitoun, Abed M, Irving, William L, Guha, Indra N, Hanley, Neil A, Hanley, Karen Piper
Format: Artigo
Language:Inglês
Published: Wiley Subscription Services, Inc., A Wiley Company 2012
Subjects:
Liver Biology/Pathobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638324/
https://ncbi.nlm.nih.gov/pubmed/22488688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25758
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