Osteopontin Is a Novel Downstream Target of SOX9 With Diagnostic Implications for Progression of Liver Fibrosis in Humans

Osteopontin (OPN) is an important component of the extracellular matrix (ECM), which promotes liver fibrosis and has been described as a biomarker for its severity. Previously, we have demonstrated that Sex-determining region Y-box 9 (SOX9) is ectopically expressed during activation of hepatic stell...

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Detalhes bibliográficos
Main Authors: Pritchett, James, Harvey, Emma, Athwal, Varinder, Berry, Andrew, Rowe, Cliff, Oakley, Fiona, Moles, Anna, Mann, Derek A, Bobola, Nicoletta, Sharrocks, Andrew D, Thomson, Brian J, Zaitoun, Abed M, Irving, William L, Guha, Indra N, Hanley, Neil A, Hanley, Karen Piper
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2012
Assuntos:
Liver Biology/Pathobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638324/
https://ncbi.nlm.nih.gov/pubmed/22488688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25758
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