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Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening

Hepatotoxicity is an enormous and increasing problem for the pharmaceutical industry. Early detection of problems during the drug discovery pathway is advantageous to minimize costs and improve patient safety. However, current cellular models are sub-optimal. This review addresses the potential use...

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Main Authors: Baxter, Melissa A., Rowe, Cliff, Alder, Jane, Harrison, Sean, Hanley, Karen Piper, Park, B. Kevin, Kitteringham, Neil R., Goldring, Chris E., Hanley, Neil A.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3556810/
https://ncbi.nlm.nih.gov/pubmed/20483202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2010.02.002
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