Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes

BACKGROUND & AIMS: Hepatocyte-like cells (HLCs), differentiated from pluripotent stem cells by the use of soluble factors, can model human liver function and toxicity. However, at present HLC maturity and whether any deficit represents a true fetal state or aberrant differentiation is unclear an...

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Publicado en:J Hepatol
Autores principales: Baxter, Melissa, Withey, Sarah, Harrison, Sean, Segeritz, Charis-Patricia, Zhang, Fang, Atkinson-Dell, Rebecca, Rowe, Cliff, Gerrard, Dave T., Sison-Young, Rowena, Jenkins, Roz, Henry, Joanne, Berry, Andrew A., Mohamet, Lisa, Best, Marie, Fenwick, Stephen W., Malik, Hassan, Kitteringham, Neil R., Goldring, Chris E., Piper Hanley, Karen, Vallier, Ludovic, Hanley, Neil A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334496/
https://ncbi.nlm.nih.gov/pubmed/25457200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2014.10.016
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