Identification of Anti-prion Compounds using a Novel Cellular Assay

Prion diseases are devastating neurodegenerative disorders with no known cure. One strategy for developing therapies for these diseases is to identify compounds that block conversion of the cellular form of the prion protein (PrP(C)) into the infectious isoform (PrP(Sc)). Most previous efforts to di...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Imberdis, Thibaut, Heeres, James T., Yueh, Han, Fang, Cheng, Zhen, Jessie, Rich, Celeste B., Glicksman, Marcie, Beeler, Aaron B., Harris, David A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207084/
https://ncbi.nlm.nih.gov/pubmed/27803163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.745612
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