A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds

Prion diseases are caused by the conversion of normal cellular prion proteins (PrP) into lethal prion aggregates. These prion aggregates are composed of proteinase K (PK) resistant fibrils and comparatively PK-sensitive oligomers. Currently there are no anti-prion pharmaceuticals available to treat...

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Detalhes bibliográficos
Publicado no:Prion
Main Authors: Ladner-Keay, Carol L., Ross, Li, Perez-Pineiro, Rolando, Zhang, Lun, Bjorndahl, Trent C., Cashman, Neil, Wishart, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277192/
https://ncbi.nlm.nih.gov/pubmed/30223704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336896.2018.1525254
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