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Nanopore Analysis of Wild-Type and Mutant Prion Protein (PrP(C)): Single Molecule Discrimination and PrP(C) Kinetics

Prion diseases are fatal neurodegenerative diseases associated with the conversion of cellular prion protein (PrP(C)) in the central nervous system into the infectious isoform (PrP(Sc)). The mechanics of conversion are almost entirely unknown, with understanding stymied by the lack of an atomic-leve...

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Detalhes bibliográficos
Main Authors: Jetha, Nahid N., Semenchenko, Valentyna, Wishart, David S., Cashman, Neil R., Marziali, Andre
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564863/
https://ncbi.nlm.nih.gov/pubmed/23393562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054982
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