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Nanopore Analysis of Wild-Type and Mutant Prion Protein (PrP(C)): Single Molecule Discrimination and PrP(C) Kinetics
Prion diseases are fatal neurodegenerative diseases associated with the conversion of cellular prion protein (PrP(C)) in the central nervous system into the infectious isoform (PrP(Sc)). The mechanics of conversion are almost entirely unknown, with understanding stymied by the lack of an atomic-leve...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3564863/ https://ncbi.nlm.nih.gov/pubmed/23393562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054982 |
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