Identification of Anti-prion Compounds using a Novel Cellular Assay

Prion diseases are devastating neurodegenerative disorders with no known cure. One strategy for developing therapies for these diseases is to identify compounds that block conversion of the cellular form of the prion protein (PrP(C)) into the infectious isoform (PrP(Sc)). Most previous efforts to di...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Imberdis, Thibaut, Heeres, James T., Yueh, Han, Fang, Cheng, Zhen, Jessie, Rich, Celeste B., Glicksman, Marcie, Beeler, Aaron B., Harris, David A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207084/
https://ncbi.nlm.nih.gov/pubmed/27803163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.745612
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items