Novel IDH1 Mutant Inhibitors for Treatment of Acute Myeloid Leukemia

Neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) are driver mutations in acute myeloid leukemia (AML) and other cancers. We report the development of new allosteric inhibitors of mutant IDH1. Crystallographic and biochemical results demonstrated that compounds of this chemical series bind t...

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Publicado no:Nat Chem Biol
Main Authors: Okoye-Okafor, Ujunwa C., Bartholdy, Boris, Cartier, Jessy, Gao, Enoch, Pietrak, Beth, Rendina, Alan R., Rominger, Cynthia, Quinn, Chad, Smallwood, Angela, Wiggall, Kenneth J., Reif, Alexander J., Schmidt, Stanley J., Qi, Hongwei, Zhao, Huizhen, Joberty, Gerard, Faelth-Savitski, Maria, Bantscheff, Marcus, Drewes, Gerard, Duraiswami, Chaya, Brady, Pat, Groy, Arthur, Narayanagari, Swathi-Rao, Antony-Debre, Ileana, Mitchell, Kelly, Wang, Heng Rui, Kao, Yun-Ruei, Christopeit, Maximilian, Carvajal, Luis, Barreyro, Laura, Paietta, Elisabeth, Makishima, Hideki, Will, Britta, Concha, Nestor, Adams, Nicholas D., Schwartz, Benjamin, McCabe, Michael T., Maciejewski, Jaroslav, Verma, Amit, Steidl, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155016/
https://ncbi.nlm.nih.gov/pubmed/26436839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1930
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