Novel IDH1 Mutant Inhibitors for Treatment of Acute Myeloid Leukemia

Neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) are driver mutations in acute myeloid leukemia (AML) and other cancers. We report the development of new allosteric inhibitors of mutant IDH1. Crystallographic and biochemical results demonstrated that compounds of this chemical series bind t...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Chem Biol
Main Authors: Okoye-Okafor, Ujunwa C., Bartholdy, Boris, Cartier, Jessy, Gao, Enoch, Pietrak, Beth, Rendina, Alan R., Rominger, Cynthia, Quinn, Chad, Smallwood, Angela, Wiggall, Kenneth J., Reif, Alexander J., Schmidt, Stanley J., Qi, Hongwei, Zhao, Huizhen, Joberty, Gerard, Faelth-Savitski, Maria, Bantscheff, Marcus, Drewes, Gerard, Duraiswami, Chaya, Brady, Pat, Groy, Arthur, Narayanagari, Swathi-Rao, Antony-Debre, Ileana, Mitchell, Kelly, Wang, Heng Rui, Kao, Yun-Ruei, Christopeit, Maximilian, Carvajal, Luis, Barreyro, Laura, Paietta, Elisabeth, Makishima, Hideki, Will, Britta, Concha, Nestor, Adams, Nicholas D., Schwartz, Benjamin, McCabe, Michael T., Maciejewski, Jaroslav, Verma, Amit, Steidl, Ulrich
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155016/
https://ncbi.nlm.nih.gov/pubmed/26436839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1930
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker