Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo

Dysregulated proteostasis is a key feature of a variety of neurodegenerative disorders. In Alzheimer’s disease (AD), progression of symptoms closely correlates with spatiotemporal progression of Tau aggregation, with “early” oligomeric Tau forms rather than mature neurofibrillary tangles (NFTs) cons...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Wang, Peng, Joberty, Gerard, Buist, Arjan, Vanoosthuyse, Alexandre, Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Pierrot, Nathalie, Faelth-Savitski, Maria, Kienlen-Campard, Pascal, Octave, Jean-Noël, Bantscheff, Marcus, Drewes, Gerard, Moechars, Diederik, Dewachter, Ilse
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2017
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5390007/
https://ncbi.nlm.nih.gov/pubmed/28083634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1663-9
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