Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo

Dysregulated proteostasis is a key feature of a variety of neurodegenerative disorders. In Alzheimer’s disease (AD), progression of symptoms closely correlates with spatiotemporal progression of Tau aggregation, with “early” oligomeric Tau forms rather than mature neurofibrillary tangles (NFTs) cons...

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Veröffentlicht in:Acta Neuropathol
Hauptverfasser: Wang, Peng, Joberty, Gerard, Buist, Arjan, Vanoosthuyse, Alexandre, Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Pierrot, Nathalie, Faelth-Savitski, Maria, Kienlen-Campard, Pascal, Octave, Jean-Noël, Bantscheff, Marcus, Drewes, Gerard, Moechars, Diederik, Dewachter, Ilse
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2017
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5390007/
https://ncbi.nlm.nih.gov/pubmed/28083634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1663-9
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