Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo

Brains of Alzheimer’s disease patients are characterized by the presence of amyloid plaques and neurofibrillary tangles, both invariably associated with neuroinflammation. A crucial role for NLRP3–ASC inflammasome [NACHT, LRR and PYD domains-containing protein 3 (NLRP3)–Apoptosis-associated speck-li...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Stancu, Ilie-Cosmin, Cremers, Niels, Vanrusselt, Hannah, Couturier, Julien, Vanoosthuyse, Alexandre, Kessels, Sofie, Lodder, Chritica, Brône, Bert, Huaux, François, Octave, Jean-Noël, Terwel, Dick, Dewachter, Ilse
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2019
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426830/
https://ncbi.nlm.nih.gov/pubmed/30721409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-018-01957-y
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