Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease

BACKGROUND: The proinflammatory cytokine interleukin-1β (IL-1β) is overexpressed in Alzheimer disease (AD) as a key regulator of neuroinflammation. Amyloid-β (Aβ) peptide triggers activation of inflammasomes, protein complexes responsible for IL-1β maturation in microglial cells. Downregulation of N...

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Publicado en:J Neuroinflammation
Main Authors: Couturier, Julien, Stancu, Ilie-Cosmin, Schakman, Olivier, Pierrot, Nathalie, Huaux, François, Kienlen-Campard, Pascal, Dewachter, Ilse, Octave, Jean-Noël
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2016
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729126/
https://ncbi.nlm.nih.gov/pubmed/26818951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0477-y
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