Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo

Genetic, clinical, histopathological and biomarker data strongly support Beta-amyloid (Aβ) induced spreading of Tau-pathology beyond entorhinal cortex (EC), as a crucial process in conversion from preclinical cognitively normal to Alzheimer‘s Disease (AD), while the underlying mechanism remains uncl...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Vasconcelos, Bruno, Stancu, Ilie-Cosmin, Buist, Arjan, Bird, Matthew, Wang, Peng, Vanoosthuyse, Alexandre, Van Kolen, Kristof, Verheyen, An, Kienlen-Campard, Pascal, Octave, Jean-Noël, Baatsen, Peter, Moechars, Diederik, Dewachter, Ilse
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789256/
https://ncbi.nlm.nih.gov/pubmed/26739002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1525-x
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