Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice

Prion-like seeding and propagation of Tau-pathology have been demonstrated experimentally and may underlie the stereotyped progression of neurodegenerative Tauopathies. However, the involvement of templated misfolding of Tau in neuronal network dysfunction and behavioral outcomes remains to be explo...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Ris, Laurence, Wang, Peng, Villers, Agnès, Peeraer, Eve, Buist, Arjan, Terwel, Dick, Baatsen, Peter, Oyelami, Tutu, Pierrot, Nathalie, Casteels, Cindy, Bormans, Guy, Kienlen-Campard, Pascal, Octave, Jean-Nöel, Moechars, Diederik, Dewachter, Ilse
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4436846/
https://ncbi.nlm.nih.gov/pubmed/25862635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1413-4
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