Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

Neurofibrillary tangles composed of hyperphosphorylated fibrillized tau are found in numerous tauopathies including Alzheimer's disease. Increasing evidence suggests that tau pathology can be transmitted from cell-to-cell; however the mechanisms involved in the initiation of tau fibrillization...

Full description

Saved in:
Bibliographic Details
Published in:Neurobiol Dis
Main Authors: Peeraer, Eve, Bottelbergs, Astrid, Van Kolen, Kristof, Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Mahieu, Michel, Duytschaever, Hilde, Ver Donck, Luc, Torremans, An, Sluydts, Ellen, Van Acker, Nathalie, Kemp, John A., Mercken, Marc, Brunden, Kurt R., Trojanowski, John Q., Dewachter, Ilse, Lee, Virginia M.Y., Moechars, Diederik
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303592/
https://ncbi.nlm.nih.gov/pubmed/25220759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.08.032
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items