Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

Neurofibrillary tangles composed of hyperphosphorylated fibrillized tau are found in numerous tauopathies including Alzheimer's disease. Increasing evidence suggests that tau pathology can be transmitted from cell-to-cell; however the mechanisms involved in the initiation of tau fibrillization...

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Publicado en:Neurobiol Dis
Main Authors: Peeraer, Eve, Bottelbergs, Astrid, Van Kolen, Kristof, Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Mahieu, Michel, Duytschaever, Hilde, Ver Donck, Luc, Torremans, An, Sluydts, Ellen, Van Acker, Nathalie, Kemp, John A., Mercken, Marc, Brunden, Kurt R., Trojanowski, John Q., Dewachter, Ilse, Lee, Virginia M.Y., Moechars, Diederik
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303592/
https://ncbi.nlm.nih.gov/pubmed/25220759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.08.032
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