Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

Neurofibrillary tangles composed of hyperphosphorylated fibrillized tau are found in numerous tauopathies including Alzheimer's disease. Increasing evidence suggests that tau pathology can be transmitted from cell-to-cell; however the mechanisms involved in the initiation of tau fibrillization...

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Udgivet i:Neurobiol Dis
Main Authors: Peeraer, Eve, Bottelbergs, Astrid, Van Kolen, Kristof, Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Mahieu, Michel, Duytschaever, Hilde, Ver Donck, Luc, Torremans, An, Sluydts, Ellen, Van Acker, Nathalie, Kemp, John A., Mercken, Marc, Brunden, Kurt R., Trojanowski, John Q., Dewachter, Ilse, Lee, Virginia M.Y., Moechars, Diederik
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303592/
https://ncbi.nlm.nih.gov/pubmed/25220759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.08.032
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