CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia

Alzheimer's disease (AD) is characterized by a sequential progression of amyloid plaques (A), neurofibrillary tangles (T) and neurodegeneration (N), constituting ATN pathology. While microglia are considered key contributors to AD pathogenesis, their contribution in the combined presence of ATN...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Lodder, Chritica, Scheyltjens, Isabelle, Stancu, Ilie Cosmin, Botella Lucena, Pablo, Gutiérrez de Ravé, Manuel, Vanherle, Sarah, Vanmierlo, Tim, Cremers, Niels, Vanrusselt, Hannah, Brône, Bert, Hanseeuw, Bernard, Octave, Jean-Noël, Bottelbergs, Astrid, Movahedi, Kiavash, Dewachter, Ilse
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8188790/
https://ncbi.nlm.nih.gov/pubmed/34103079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01204-8
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