HSC commitment–associated epigenetic signature is prognostic in acute myeloid leukemia

Acute myeloid leukemia (AML) is characterized by disruption of HSC and progenitor cell differentiation. Frequently, AML is associated with mutations in genes encoding epigenetic modifiers. We hypothesized that analysis of alterations in DNA methylation patterns during healthy HSC commitment and diff...

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Autors principals: Bartholdy, Boris, Christopeit, Maximilian, Will, Britta, Mo, Yongkai, Barreyro, Laura, Yu, Yiting, Bhagat, Tushar D., Okoye-Okafor, Ujunwa C., Todorova, Tihomira I., Greally, John M., Levine, Ross L., Melnick, Ari, Verma, Amit, Steidl, Ulrich
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934187/
https://ncbi.nlm.nih.gov/pubmed/24487588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71264
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