HSC commitment–associated epigenetic signature is prognostic in acute myeloid leukemia

Acute myeloid leukemia (AML) is characterized by disruption of HSC and progenitor cell differentiation. Frequently, AML is associated with mutations in genes encoding epigenetic modifiers. We hypothesized that analysis of alterations in DNA methylation patterns during healthy HSC commitment and diff...

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Autori principali: Bartholdy, Boris, Christopeit, Maximilian, Will, Britta, Mo, Yongkai, Barreyro, Laura, Yu, Yiting, Bhagat, Tushar D., Okoye-Okafor, Ujunwa C., Todorova, Tihomira I., Greally, John M., Levine, Ross L., Melnick, Ari, Verma, Amit, Steidl, Ulrich
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934187/
https://ncbi.nlm.nih.gov/pubmed/24487588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71264
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