HSC commitment–associated epigenetic signature is prognostic in acute myeloid leukemia

Acute myeloid leukemia (AML) is characterized by disruption of HSC and progenitor cell differentiation. Frequently, AML is associated with mutations in genes encoding epigenetic modifiers. We hypothesized that analysis of alterations in DNA methylation patterns during healthy HSC commitment and diff...

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Detalhes bibliográficos
Main Authors: Bartholdy, Boris, Christopeit, Maximilian, Will, Britta, Mo, Yongkai, Barreyro, Laura, Yu, Yiting, Bhagat, Tushar D., Okoye-Okafor, Ujunwa C., Todorova, Tihomira I., Greally, John M., Levine, Ross L., Melnick, Ari, Verma, Amit, Steidl, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934187/
https://ncbi.nlm.nih.gov/pubmed/24487588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71264
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