H2.0-like homeobox (HLX) regulates early hematopoiesis and promotes acute myeloid leukemia

Homeobox domain-containing transcription factors are important regulators of hematopoiesis. Here we report that increased levels of non-clustered H2.0-like homeobox (HLX) lead to loss of functional hematopoietic stem cells and formation of aberrant progenitors with unlimited serial clonogenicity and...

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Hauptverfasser: Kawahara, Masahiro, Pandolfi, Ashley, Bartholdy, Boris, Barreyro, Laura, Will, Britta, Roth, Michael, Okoye-Okafor, Ujunwa C., Todorova, Tihomira I., Figueroa, Maria E., Melnick, Ari, Mitsiades, Constantine S., Steidl, Ulrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422691/
https://ncbi.nlm.nih.gov/pubmed/22897850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.06.027
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