A structure-function approach to optimizing TLR4 ligands for human vaccines

Adjuvants are combined with vaccine antigens to enhance and modify immune responses, and have historically been primarily crude, undefined entities. Introducing toll-like receptor (TLR) ligands has led to a new generation of adjuvants, with TLR4 ligands being the most extensively used in human vacci...

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Detalhes bibliográficos
Publicado no:Clin Transl Immunology
Main Authors: Carter, Darrick, Fox, Christopher B, Day, Tracey A, Guderian, Jeffrey A, Liang, Hong, Rolf, Tom, Vergara, Julie, Sagawa, Zachary K, Ireton, Greg, Orr, Mark T, Desbien, Anthony, Duthie, Malcolm S, Coler, Rhea N, Reed, Steven G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133366/
https://ncbi.nlm.nih.gov/pubmed/27990284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cti.2016.63
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