Optimizing manufacturing and composition of a TLR4 nanosuspension: physicochemical stability and vaccine adjuvant activity

BACKGROUND: Nanosuspensions are an important class of delivery system for vaccine adjuvants and drugs. Previously, we developed a nanosuspension consisting of the synthetic TLR4 ligand glucopyranosyl lipid adjuvant (GLA) and dipalmitoyl phosphatidylcholine (DPPC). This nanosuspension is a clinical v...

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Detalhes bibliográficos
Main Authors: Fung, HW Millie, Mikasa, Traci JT, Vergara, Julie, Sivananthan, Sandra J, Guderian, Jeffrey A, Duthie, Malcolm S, Vedvick, Thomas S, Fox, Christopher B
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3881025/
https://ncbi.nlm.nih.gov/pubmed/24359024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-3155-11-43
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