Cooperative intracellular interactions between MyD88 and TRIF are required for CD4 T cell T(H)1 polarization with a synthetic TLR4 agonist adjuvant

GLA-SE is a synthetic adjuvant agonist of TLR4 that promotes potent poly-functional T(H)1 responses. Different TLR4 agonists may preferentially signal via MyD88 or TRIF to exert adjuvant effects. However the contribution of MyD88 and TRIF signaling to the induction of polyclonal T(H)1 responses by T...

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Autors principals: Orr, Mark T., Duthie, Malcolm S., Windish, Hillarie Plessner, Lucas, Elyse A., Guderian, Jeff, Hudson, Thomas E., Shaverdian, Narek, O’Donnell, Joanne, Desbien, Anthony L., Reed, Steven G., Coler, Rhea N.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3803998/
https://ncbi.nlm.nih.gov/pubmed/23716300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201243124
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