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Autoimmune susceptibility imposed by public TCRβ chains

Although the TCR repertoire is highly diverse, a small fraction of TCR chains, referred to as public, preferentially form and are shared by most individuals. Prior studies indicated that public TCRβ may be preferentially deployed in autoimmunity. We hypothesized that if these TCRβ modulate the likel...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhao, Yunqian, Nguyen, Phuong, Vogel, Peter, Li, Bofeng, Jones, Lindsay L., Geiger, Terrence L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116635/
https://ncbi.nlm.nih.gov/pubmed/27869234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37543
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