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Altered differentiation, diminished pathogenicity, and regulatory activity of myelin-specific T cells expressing an enhanced affinity TCR

Whereas increased affinity enhances T cell competitiveness after immunization, the role of affinity in modulating the pathogenicity of self-reactive T cells is less established. To assess this, we generated two myelin-specific, class II MHC-restricted TCR that differ only in a buried hydroxymethyl t...

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Библиографические подробности
Главные авторы: Alli, Rajshekhar, Nguyen, Phuong, Geiger, Terrence L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221875/
https://ncbi.nlm.nih.gov/pubmed/22025553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102202
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