TCR affinity and specificity requirements for human regulatory T-cell function

We investigated whether TCRs restricted to the more ubiquitously expressed MHC class I molecules could be used to redirect human regulatory T cells (Tregs). Using a series of HLA-A2–restricted TCRs that recognize the same peptide-MHC class I complex (pMHC) with affinities varying up to 3500 fold, we...

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Detalhes bibliográficos
Main Authors: Plesa, Gabriela, Zheng, Lingjie, Medvec, Andrew, Wilson, Caleph B., Robles-Oteiza, Camila, Liddy, Nathaniel, Bennett, Alan D., Gavarret, Jessie, Vuidepot, Annelise, Zhao, Yangbing, Blazar, Bruce R., Jakobsen, Bent K., Riley, James L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325034/
https://ncbi.nlm.nih.gov/pubmed/22318202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-377051
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