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Different affinity windows for virus and cancer-specific T-cell receptors – implications for therapeutic strategies
T-cell destiny during thymic selection depends on the affinity of the T-cell receptor (TCR) for autologous peptide ligands presented in the context of MHC molecules. This is a delicately balanced process; robust binding leads to negative selection, yet some affinity for the antigen complex is requir...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3776049/ https://ncbi.nlm.nih.gov/pubmed/22949370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201242606 |
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