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Therapeutic Strategies to Alter Oxygen Affinity of Sickle Hemoglobin
The fundamental pathophysiology of sickle cell disease involves the polymerization of sickle hemoglobin in its T-state which develops under low oxygen saturation. One therapeutic strategy is to develop pharmacologic agents to stabilize the R-state of hemoglobin, which has higher oxygen affinity and...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4195245/ https://ncbi.nlm.nih.gov/pubmed/24589263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hoc.2013.11.001 |
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