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Retrogenic modeling of experimental allergic encephalomyelitis associates T-cell frequency but not T-cell receptor functional affinity with pathogenicity
The properties of a self-specific T-cell's TCR that determine its pathogenicity are not well understood. We developed TCR retroviral transgenic, or retrogenic, models of myelin oligodendroglial glycoprotein (MOG)-induced EAE to compare the pathologic potential of five H-2 A(b)/MOG(35-55)-specif...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2615687/ https://ncbi.nlm.nih.gov/pubmed/18566378 |
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