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Retrogenic modeling of experimental allergic encephalomyelitis associates T-cell frequency but not T-cell receptor functional affinity with pathogenicity

The properties of a self-specific T-cell's TCR that determine its pathogenicity are not well understood. We developed TCR retroviral transgenic, or retrogenic, models of myelin oligodendroglial glycoprotein (MOG)-induced EAE to compare the pathologic potential of five H-2 A(b)/MOG(35-55)-specif...

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Hlavní autoři: Alli, Rajshekhar, Nguyen, Phuong, Geiger, Terrence L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615687/
https://ncbi.nlm.nih.gov/pubmed/18566378
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