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Rational Design of T Cell Receptors with Enhanced Sensitivity for Antigen
Enhancing the affinity of therapeutic T cell receptors (TCR) without altering their specificity is a significant challenge for adoptive immunotherapy. Current efforts have primarily relied on empirical approaches. Here, we used structural analyses to identify a glycine-serine variation in the TCR th...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3063236/ https://ncbi.nlm.nih.gov/pubmed/21455495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018027 |
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