A carregar...
Subtle affinity-enhancing mutations in a MOG-specific TCR alter specificity and generate new self-reactivity
We describe a simple iterative approach to augment TCR affinity, which we studied using a myelin oligodendroglial glycoprotein (MOG)-specific TCR. We hypothesized that single amino acid modifications in T-cell receptor (TCR) CDR3 could enhance TCR sensitivity through focal interactions with antigeni...
Na minha lista:
| Main Authors: | , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2681418/ https://ncbi.nlm.nih.gov/pubmed/19299745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804377 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|