Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections

[Image: see text] Gram-negative uropathogenic Escherichia coli (UPEC) bacteria are a causative pathogen of urinary tract infections (UTIs). Previously developed antivirulence inhibitors of the type 1 pilus adhesin, FimH, demonstrated oral activity in animal models of UTI but were found to have limit...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:J Med Chem
Hoofdauteurs: Mydock-McGrane, Laurel, Cusumano, Zachary, Han, Zhenfu, Binkley, Jana, Kostakioti, Maria, Hannan, Thomas, Pinkner, Jerome S., Klein, Roger, Kalas, Vasilios, Crowley, Jan, Rath, Nigam P., Hultgren, Scott J., Janetka, James W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2016
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087331/
https://ncbi.nlm.nih.gov/pubmed/27689912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00948
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items