Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections

[Image: see text] Gram-negative uropathogenic Escherichia coli (UPEC) bacteria are a causative pathogen of urinary tract infections (UTIs). Previously developed antivirulence inhibitors of the type 1 pilus adhesin, FimH, demonstrated oral activity in animal models of UTI but were found to have limit...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Mydock-McGrane, Laurel, Cusumano, Zachary, Han, Zhenfu, Binkley, Jana, Kostakioti, Maria, Hannan, Thomas, Pinkner, Jerome S., Klein, Roger, Kalas, Vasilios, Crowley, Jan, Rath, Nigam P., Hultgren, Scott J., Janetka, James W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087331/
https://ncbi.nlm.nih.gov/pubmed/27689912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00948
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