Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI

Uropathogenic E. coli (UPEC) employ the mannose-binding adhesin FimH to colonize the bladder epithelium during urinary tract infection (UTI). Previously reported FimH antagonists exhibit good potency and efficacy, but low bioavailability and a short half-life in vivo. In a rational design strategy,...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Jarvis, Cassie, Han, Zhenfu, Kalas, Vasilios, Klein, Roger, Pinkner, Jerome S., Ford, Bradley, Binkley, Jana, Cusumano, Corinne K., Cusumano, Zachary, Mydock-McGrane, Laurel, Hultgren, Scott J., Janetka, James W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818977/
https://ncbi.nlm.nih.gov/pubmed/26812660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600006
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados