Characterization of parasite-specific indels and their proposed relevance for selective anthelminthic drug targeting

Por Wang, Qi, Heizer, Esley, Rosa, Bruce A., Wildman, Scott A., Janetka, James W., Mitreva, Makedonka
Publicado no Infect Genet Evol (2016)

Distinguishing the Contribution of Type 1 Pili from That of Other QseB-Misregulated Factors when QseC Is Absent during Urinary Tract Infection

Por Kostakioti, Maria, Hadjifrangiskou, Maria, Cusumano, Corinne K., Hannan, Thomas J., Janetka, James W., Hultgren, Scott J.
Publicado em 2012

A FimH Inhibitor Prevents Acute Bladder Infection and Treats Chronic Cystitis Caused by Multidrug-Resistant Uropathogenic Escherichia coli ST131

Por Totsika, Makrina, Kostakioti, Maria, Hannan, Thomas J., Upton, Mathew, Beatson, Scott A., Janetka, James W., Hultgren, Scott J., Schembri, Mark A.
Publicado em 2013

Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer

Por Han, Zhenfu, Harris, Peter K. W., Jones, Darin E., Chugani, Ryan, Kim, Tommy, Agarwal, Manjula, Shen, Wei, Wildman, Scott A., Janetka, James W.
Publicado no ACS Med Chem Lett (2014)

Lead Optimization Studies on FimH Antagonists: Discovery of Potent and Orally Bioavailable Ortho-substituted Biphenyl Mannosides

Por Han, Zhenfu, Pinkner, Jerome S., Ford, Bradley, Chorell, Erik, Crowley, Jan M., Cusumano, Corinne K., Campbell, Scott, Henderson, Jeffrey P., Hultgren, Scott J., Janetka, James W.
Publicado em 2012

Combinatorial Small-Molecule Therapy Prevents Uropathogenic Escherichia coli Catheter-Associated Urinary Tract Infections in Mice

Por Guiton, Pascale S., Cusumano, Corinne K., Kline, Kimberly A., Dodson, Karen W., Han, Zhenfu, Janetka, James W., Henderson, Jeffrey P., Caparon, Michael G., Hultgren, Scott J.
Publicado em 2012

Treatment and Prevention of Urinary Tract Infection with Orally Active FimH Inhibitors

Por Cusumano, Corinne K., Pinkner, Jerome S., Han, Zhenfu, Greene, Sarah E., Ford, Bradley A., Crowley, Jan R., Henderson, Jeffrey P., Janetka, James W., Hultgren, Scott J.
Publicado em 2011

Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists

Por Han, Zhenfu, Pinkner, Jerome S., Ford, Bradley, Obermann, Robert, Nolan, William, Wildman, Scott A., Hobbs, Doug, Ellenberger, Tom, Cusumano, Corinne K., Hultgren, Scott J., Janetka, James W.
Publicado em 2010

Click chemistry reagent for identification of sites of covalent ligand incorporation in integral membrane proteins

Por Budelier, Melissa M., Cheng, Wayland W. L., Bergdoll, Lucie, Chen, Zi-Wei, Abramson, Jeff, Krishnan, Kathiresan, Qian, Mingxing, Covey, Douglas F., Janetka, James W., Evers, Alex S.
Publicado no Anal Chem (2017)

Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI

Por Jarvis, Cassie, Han, Zhenfu, Kalas, Vasilios, Klein, Roger, Pinkner, Jerome S., Ford, Bradley, Binkley, Jana, Cusumano, Corinne K., Cusumano, Zachary, Mydock-McGrane, Laurel, Hultgren, Scott J., Janetka, James W.
Publicado no ChemMedChem (2016)

Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections

Por Mydock-McGrane, Laurel, Cusumano, Zachary, Han, Zhenfu, Binkley, Jana, Kostakioti, Maria, Hannan, Thomas, Pinkner, Jerome S., Klein, Roger, Kalas, Vasilios, Crowley, Jan, Rath, Nigam P., Hultgren, Scott J., Janetka, James W.
Publicado no J Med Chem (2016)